Now we also know what the interconnections look like at a molecular level. "It has been obvious for some time that there is an association between the body's own cortisol or therapeutically administered cortisone and the development of fatty liver. "We have discovered a key mechanism here that plays a crucial role in many pathologic metabolic disorders," explains Stephan Herzig. Further experiments have shown that the cortisol receptor in this newly found metabolic pathway act directly on a switch of the HES1 gene and, thus, switches it off completely. If, on other hand, normal mice are treated with cortisol, their HES1 levels in the liver drops, while triglyceride levels rise. HES1 activates a number of enzymes that break down fat and, thus, counteracts fat accumulation in the liver. As a result, a preventive health checkup is. This means that the creatinine level in the blood stream can be used to track how well the kidneys are clearing waste products: if a persons kidney function. High creatinine levels may be a sign of significant kidney problems. Raised blood creatinine levels can have a variety of causes, all of which must be addressed. Investigations have revealed that, in the absence of the cortisol receptor, large amounts of the HES1 protein are produced in the livers of these animals. Creatinine Levels Must Be Reduced to maintain Kidney health: Creatinine is a waste product that the kidneys are supposed to get rid of. As a result, the triglyceride level in the livers of the experimental animals dropped considerably. The researchers in Herzig's team specifically switched off the cortisol receptor in the livers of mice, thus blocking the hormone's effect.
Stephan Herzig, head of the Junior Research Group "Molecular Metabolic Control" at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), and his team have now published the mechanism by which the body's own glucocorticoid hormones contribute to this disruption of the lipid metabolism. Additionally, a study in the International Journal of. But talk to your doctor about what type and amount of fluids are best. According to the Mayo Clinic, drinking eight 8-oz glasses of water each day is a reasonable goal that is appropriate for many people. Long-term cortisone therapies such as those used for treating chronic inflammatory diseases such as asthma also cause the triglyceride level in the liver to rise to dangerous levels.ĭr. Creatine supplements have not been shown to adversely affect the liver during short-term, low-dose usage. Dehydration may increase creatinine levels, so increasing your fluid intake will help avoid dehydration and possibly improve your creatinine. This, in turn, leads to high blood sugar levels and patients frequently develop fatty liver. Cortisol levels in affected patients are permanently raised – often caused by malignant tumors. This can be observed, for example, in a condition known as Cushing syndrome.
However, scientists knew that the body's own glucocorticoid hormones such as cortisol promote the development of fatty liver. It was still unknown which conditions cause the body to deposit fat in the liver.
0 kommentar(er)
